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Itraconazole Capsule

Itraconazole Capsule
Itraconazole Capsule
Price And Quantity
    Product Specifications
    • Other Types
    Product Description

    Itraconazole Capsule is antifungal medicine which is indicated for treating aspergillosis, blastomycosis, and coccidiomycosis. It is highly effective in nature and is known to work by inhibiting ergosterol synthesis which causes fungal dearth. Active compound present in this medicine has molecular formula C35H38Cl2N8O4 with molar mass of 705.64 g/mol. It is metabolized in liver with help of CYP3A4 and shows protein binding ability of 99.8%. Itraconazole Capsule exerts its activity by inhibiting lanosterol 14-alpha-demethylase enzyme.

    Features:

    • Belongs to triazole medicine family
    • Fast mode of action
    • Disrupts cell membrane of fungi to fight infections

     

     

    Monograph

    MedlinePlus

    a692049

    Pregnancy
    category

    • AU: B3
    • US: C (Risk not ruled out)

     

    Routes of
    administration

    By mouth (capsulessolution), local (vaginal suppository), IV; By mouth only (UK and US)

    ATC code

     

    Legal status

    Legal status

     

    Pharmacokinetic data

    Bioavailability

    ~55%, maximal if taken with full meal

    Protein binding

    99.8%

    Metabolism

    Extensive in liver (CYP3A4)

    Metabolites

    Hydroxy-itraconazole, keto-itraconazole,
    N-desalkyl-itraconazole
    [1]

    Elimination half-life

    21 hours

    Excretion

    Urine (35%), faeces (54%)[2]

    Identifiers

    IUPAC name[show]

    CAS Number

     

    PubChem CID

     

    DrugBank

     

    ChemSpider

     

    UNII

     

    KEGG

     

    ChEBI

     

    ChEMBL

     

    ECHA InfoCard

    100.123.596 Edit this at Wikidata

    Chemical and physical data

    Formula

    C35H38Cl2N8O4

    Molar mass

    705.64

    3D model (JSmol)

     

    Chirality

    Racemic mixture

    SMILES[show]

    InChI[show]

      (verify)

    Itraconazole is an antifungal medication used to treat a number of fungal infections.[3] This includes aspergillosisblastomycosiscoccidioidomycosishistoplasmosis, and paracoccidioidomycosis.[3] It may be given by mouth or intravenously.[3]

    Common side effects include nausea, diarrhea, abdominal pain, rash, and headache.[3] Severe side effects may include liver problemsheart failureStevens-Johnson syndrome and allergic reactions including anaphylaxis.[3] It is unclear if use during pregnancy or breastfeeding is safe.[4] It is in the triazole family of medications.[3] It stops fungal growth by affecting the cell membrane or affecting their metabolism

     

    Trade Information
    • 3-7 Days
    • Sample costs shipping and taxes has to be paid by the buyer
    • 10*1*4 BLISTER
    • Asia
    • All India
    Contact Us

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    Phone :08146661840